It is difficult to know exactly when the shift from gelatine to agar occurred. As often happens for scientific breakthroughs, agar was likely adopted incrementally alongside the use of other growth media. In 1913, for example, the first diagnosis of Serratia marcescens as a human pathogen was made by growing it on agar as well as on potatoes.
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我国知识产权发展从无到有、由弱变强、由多向优，专利思维、版权意识、品牌文化深入人心，尊重知识、鼓励创新的社会氛围越来越浓。今天，从知识产权大国迈向知识产权强国，我国保护知识产权的决心更加坚定，创新创造的活力也必将进一步迸发。
"That will need to be paid off at some point," says Quilter Cheviot's Ben Barringer. "Having more debt means you've got more burden, and that means you've got less to spend on content."
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The tradeoff is complexity. The microcode must be carefully arranged so that the instructions in delay slots are either useful setup for both paths, or at least harmless if the redirect fires. Not every case is as clean as RETF. When a PLA redirect interrupts an LCALL, the return address is already pushed onto the microcode call stack (yes, the 386 has a microcode call stack) -- the redirected code must account for this stale entry. When multiple protection tests overlap, or when a redirect fires during a delay slot of another jump, the control flow becomes hard to reason about. During the FPGA core implementation, protection delay slot interactions were consistently the most difficult bugs to track down.
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